Standard No.:	GB/T 15670.12-2017
Chinese Name:	农药登记毒理学试验方法 第12部分：短期重复吸入染毒(28天)毒性试验
English Name:	Toxicological test methods for pesticides registration—Part 12:Short-term repeated dose 28-day inhalation toxicity study
Professional Classification:	B17 Pesticide management and application method
ICS Classification:	65.100
Issued by:
Issued on:	2017-07-12
Implemented on:	2018-02-01
Status:	VALID
Language:	English
File Format:	PDF
Word Count:	6000 words
Price(USD):	180 (USD)
Delivery:	via email in 1-3 business day

GB/T 15670 consists of the following parts under the general title Toxicological test methods for pesticides registration:

——Part 1: General principles;

——Part 2: Acute oral toxicity test - Horn's method;

——Part 3: Acute oral toxicity test - Up-and-down-procedure;

——Part 4: Acute oral toxicity test - Up-and-down-procedure;

——Part 5: Acute dermal toxicity test;

——Part 6: Acute inhalation toxicity test;

——Part 7: Dermal irritation/corrosion test;

——Part 8: Acute eye irritation/corrosion test;

——Part 9: Skin sensitisation test;

——Part 10: Short-term repeated dose 28-day oral toxicity study;

——Part 11: Short-term repeated dose 28-day dermal toxicity study;

——Part 12: Short-term repeated dose 28-day inhalation toxicity study;

——Part 13: Subchronic toxicity study;

——Part 14: Bacterial reverse mutation test;

——Part 15: In vivo mammalian bone marrow polychromatic erythrocyte micronucleus test;

——Part 16: In vivo mammalian bone marrow cell chromosome aberration test;

——Part 17: Mammalian spermatogonial/spermatocyte chromosome aberration test;

——Part 18: Rodent dominant lethal test;

——Part 19: In vitro mammalian cells chromosome aberration test;

——Part 20: In vitro mammalian cell gene mutation test;

——Part 21: Unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo;

——Part 22: DNA damage and repair/unscheduled DNA synthesis test in mammalian cells in vivo;

——Part 23: Teratogenicity study;

——Part 24:Two-generation reproduction toxicity study;

——Part 25: Acute delayed neurotoxicity test;

——Part 26: Chronic toxicity study;

——Part 27: Carcinogenicity study;

——Part 28: Combined chronic toxicity/carcinogenicity study;

——Part 29: Metabolism and toxicokinetics study.

This part is Part 12 of GB/T 15670.


1 Scope

This part of GB/T 15670 specifies the basic principles, methods and requirements of short-term repeated dose 28-day inhalation toxicity study.

This part is applicable to short-term repeated dose 28-day inhalation toxicity study performed for pesticides registration.

2 Normative references

The following referenced documents are indispensable for the application of this document. For dated references, only the edition cited applies. For undated references, the latest edition of the referenced document (including any amendments) applies.

GB 14925 Laboratory animal - Requirements of environment and housing facilities

3 Terms and definitions

For the purposes of this document, the following terms and definitions apply.

3.1
short-term repeated dose inhalation toxicity
adverse health effect caused by repeated inhalation of the test object for a period less than 10% of the life of laboratory animal

3.2
inhaled dose
the amount of test object inhaled per unit body weight of animal, i.e.: